Antigen capturing nanoparticles for use in cancer immunotherapy
AssigneeThe University of North Carolina at Chapel Hill
InventorsAndrew Wang, Yuanzeng Min, Zach Rodgers
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Abstract
Disclosed herein are antigen-capturing nanoparticles. Specifically, the subject matter contained herein pertains to novel nanoparticles that can capture a multitude of tumor antigens that are released from tumor cells. Also, provided herein are methods for preparing the antigen-capturing nanoparticles and methods for the treatment of disease in a subject comprising administering the antigen-capturing nanoparticles.
Claims19
A method of enhancing or inducing an immune response in a subject having cancer comprising:
- administering to the subject a nanoparticle comprising:
- a core, wherein said core comprises
- Polymer-X-J,
- wherein,
- X is PEG′ or a linker;
- and
- J is a reactive group, wherein at least a portion of said J is present on the surface of said core and at least one of said J present on said surface is covalently bound to PEP-PEG″, and wherein PEP is a protein sequence, wherein said protein sequence is a protease sensitive protein sequence;
- wherein the nanoparticle is free from any antigen prior to the administration to the subject.
A method of treating, alleviating, ameliorating, relieving, delaying onset of, inhibiting progression of, reducing severity of, or reducing incidence of one or more symptoms or features of a disease, disorder, or condition in a subject comprising administering to a subject a nanoparticle comprising:
- a core,
- wherein said core comprises Polymer-X-J,
- wherein, X is PEG′ or a linker;
- and J is a reactive group,
- wherein at least a portion of said J is present on the surface of said core and at least one of said J present on said surface is covalently bound to PEP-PEG″, wherein PEP is a protein sequence, wherein said protein sequence is a protease sensitive protein sequence, and
- wherein the nanoparticle is free from any antigen prior to the administration to the subject;
- wherein the administration of the nanoparticle enhances an immune response.
A method of treating, alleviating, ameliorating, relieving, delaying onset of, inhibiting progression of, reducing severity of, or reducing incidence of one or more symptoms of a cancer in a subject comprising
- providing a nanoparticle comprising a core,
- wherein said core comprises Polymer-X-J, wherein, X is PEG′ or a linker;
- and J is a reactive group,
- wherein at least a portion of said J is present on the surface of said core and at least one of said J present on said surface is covalently bound to PEP-PEG″,
- wherein PEP is a protein sequence, wherein said protein sequence is a protease sensitive protein sequence, and
- wherein the nanoparticle is free from any antigen;
- and
- administering the nanoparticle to a subject,
- wherein said cancer is at least partially necrotizing, and
- the nanoparticle binds at least one antigen released from said at least partially necrotizing cancer.
Dependencies are inferred from the claim text.