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US 11,446,389 B2Granted
Maytansinoid derivatives, conjugates thereof, and methods of use
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsThomas Nittoli, Thomas P. Markotan
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Abstract
Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
Claims19
A method of treating a proliferative disorder comprising administering to a patient having said disorder a therapeutically effective amount of compound of Formula II:
- or a pharmaceutically acceptable salt or stereoisomer thereof,
- wherein A is arylene or heteroarylene;
- and
- wherein the proliferative disorder is ovarian cancer, prostate cancer, or breast cancer.
1 more element
Dependencies are inferred from the claim text.