US 11,446,386 B2 · Anti-CDH6 antibody and method of producing an anti-CDH6 antibody-drug conjugate

Abstract

It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Claims18

Dependent claims

A human or humanized monoclonal antibody that specifically binds to the amino acid sequence shown of SEQ ID NO:

4 and possesses an ability to internalize that permits cellular uptake, or a functional fragment of the antibody that binds to the amino acid sequence of SEO ID NO:
4 and possesses an ability to internalize that permits cellular uptake.

Dependencies are inferred from the claim text.

Facts

Application

16/613,203Filed 14 May 2018

Priority

JP JP2017-09674915 May 2017

Published

US 2020/0171163 A14 Jun 2020

Granted

20 Sep 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification35 codes

A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/0021
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/08
Medicinal preparations characterised by special physical form: solutions
A61K 9/19
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: lyophilised , i.e.…

Anti-CDH6 antibody and method of producing an anti-CDH6 antibody-drug conjugate

Life of this patent

Anti-CDH6 antibody and method of producing an anti-CDH6 antibody-drug conjugate

Life of this patent

Abstract

Claims18