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US 11,446,385 B2Granted
Polymer derivatives having particular atom arrangements
AssigneeNektar Therapeutics
InventorsJ. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
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Abstract
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
Claims15
A water-soluble polymer conjugate having a structure:
- wherein:
- POLY1 is a linear water-soluble polymer;
- (a) is 0, 1, 2 or 3;
- (b) is 0, 1, 2 or 3;
- R1 is H or an organic radical;
- X1, when present, is a first spacer moiety;
- X2, when present, is a second spacer moiety;
- and
- Active Agent is a pharmacologically active agent selected from the group consisting of small molecules, peptides, polypeptides, and proteins.
6 more elements
Dependencies are inferred from the claim text.