Back to results
US 11,446,382 B2Granted
Animal protein-free pharmaceutical compositions
AssigneeAllergan, Inc.
InventorTerrence J. Hunt
Life of this patent
Estimating the term…
Abstract
Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.
Claims30
A pharmaceutical composition, comprising:
- (a) a biologically active serotype A botulinum toxin,
- (b) a surfactant, and
- (c) an antioxidant selected from the group consisting of:
- citrate and a single amino acid, wherein the pharmaceutical composition is (i) stable, (ii) suitable for intramuscular or subcutaneous injection, and (iii) animal protein free and polysaccharide free.
1 more element
A pharmaceutical composition, comprising:
- (a) a biologically active serotype A botulinum toxin,
- (b) at least one surfactant selected from the group consisting of:
- poloxamer and polysorbate,
- (c) at least one antioxidant selected from the group consisting of citrate and a single amino acid,
- (d) sodium chloride;
- and
- (e) an aqueous carrier,
- wherein the pharmaceutical composition has a pH of about 5 to about 7.3, and
- wherein the pharmaceutical composition is (i) stable, (ii) suitable for intramuscular or subcutaneous injection, and (iii) animal protein free and polysaccharide free.
6 more elements
A pharmaceutical composition, comprising:
- (a) a biologically active serotype A botulinum toxin, wherein the botulinum toxin is pure approximately 150 kDa toxin,
- (b) at least one surfactant selected from the group consisting of:
- poloxamer and polysorbate,
- (c) at least one antioxidant selected from the group consisting of citrate and a single amino acid,
- (d) about 0.9% w/v sodium chloride,
- (e) about 10 mM phosphate buffer;
- and
- (f) an aqueous carrier,
- wherein the pharmaceutical composition has a pH of about 5 to about 7.3, and
- wherein the formulation is (i) stable, (ii) suitable for intramuscular or subcutaneous injection, and (iii) animal protein free, disaccharide free, and polysaccharide free.
7 more elements
A pharmaceutical composition, comprising:
- (a) a biologically active serotype A botulinum toxin, wherein the botulinum toxin is pure approximately 150 kDa toxin,
- (b) at least one polysorbate surfactant,
- (c) at least one amino acid antioxidant,
- (d) sodium chloride present in an amount that renders the pharmaceutical composition isotonic,
- (e) about 10 mM phosphate buffer;
- and
- (f) an aqueous carrier,
- wherein the pharmaceutical composition has a pH of about 5 to about 7.3, and
- wherein the formulation is (i) stable, (ii) suitable for intramuscular or subcutaneous injection, and (iii) animal protein free, disaccharide free, and polysaccharide free.
6 more elements
Dependencies are inferred from the claim text.