Monoclonal antibodies that bind to SSEA4 and uses thereof
AssigneeCHO Pharma USA, Inc.
InventorLan Bo Chen
Life of this patent
Estimating the term…
Abstract
A nucleic acid construct that encodes a monoclonal antibody or antigen-binding fragment that specifically binds to stage-specific embryonic antigen 4. The monoclonal antibody or antigen-binding fragment includes a heavy-chain CDR1 having the sequence of SEQ ID NO: 33 or SEQ ID NO: 40, a heavy-chain CDR2 having the sequence of SEQ ID NO: 34 or SEQ ID NO: 39, a heavy-chain CDR3 having the sequence of SEQ ID NO: 35 or SEQ ID NO: 41, a light-chain CDR1 having the sequence of SEQ ID NO: 36 or SEQ ID NO: 42, a light-chain CDR2 having the sequence of SEQ ID NO: 37 or SEQ ID NO: 43, and a light-chain CDR3 having the sequence of SEQ ID NO: 38 or SEQ ID NO: 44. Also disclosed are recombinant cells containing the nucleic acid construct.
Claims14
A nucleic acid construct that encodes a monoclonal antibody, the construct encoding a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO:
- 33, a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO:
- 34, a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO:
- 35, a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO:
- 42, a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO:
- 43, and a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO:
- 44,
- wherein the monoclonal antibody specifically binds to stage-specific embryonic antigen 4.
A nucleic acid construct that encodes a monoclonal antibody having a heavy-chain sequence of SEQ ID NO:
- 2and SEQ ID NO:
- 26;
- and a light-chain sequence of SEQ ID NO:
- 4;
- a heavy-chain sequence of SEQ ID NO:
- 6 and a light-chain sequence of SEQ ID NO:
- 8;
- or a heavy-chain sequence of SEQ ID NO:
- 14 and a light-chain sequence of SEQ ID NO:
- 28, SEQ ID NO:
- 30, or SEQ ID NO:
- 32, wherein the monoclonal antibody specifically binds to stage-specific embryonic antigen 4.
Dependencies are inferred from the claim text.