Endothelium-specific nucleic acid regulatory elements and methods and use thereof
AssigneeVrije Universiteit Brussel
InventorsMarinee Chuah, Thierry Vandendriessche
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Abstract
The present invention relates to nucleic acid regulatory elements that are able to enhance endothelial cell-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly endothelial cell-directed gene therapy, and for vaccination purposes.
Claims21
A nucleic acid regulatory element for enhancing endothelial cell specific gene expression consisting of a sequence selected from the group consisting of SEQ ID NOS:
- 3, 4, 5, 6, 7, 9, 10, 11, 15, 18, 21, 22, 24, 25, 28, 29 and 30.
A nucleic acid regulatory element for enhancing endothelial cell-specific gene expression consisting of the sequence of SEQ ID NO:
- 1.
A nucleic acid regulatory element for enhancing gene expression in endothelial cells consisting of a complement of a sequence as defined by any one of SEQ ID NOS:
- 3, 4, 5, 6, 7, 9, 10, 11, 15, 18, 21, 22, 24, 25, 28, 29 or 30.
Dependencies are inferred from the claim text.