Stable, spray dried, immunogenic, viral compositions
AssigneeInternational AIDS Vaccine Initiative
InventorsTom Jin, Eric I-Fu Tsao
Life of this patent
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Abstract
Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, MVA viruses, and baculoviruses which encode one or more antigens of interest, such as TB, malarial, and HIV antigens, are spray dried with a mannitol-cyclodextrin-trehalose-dextran (MCTD) to form a powder where the viability of the viruses are maintained at a suitable level for mass vaccinations after spray drying, and where the viability of the viruses are maintained at suitable level over a period of storage time, even in the presence of humidity.
Claims24
An immunogenic composition having low hygroscopicity, comprising:
- one or more live viruses in a powder formulation spray dried from a composition comprising mannitol at 10-150 mg/ml, cyclodextrin at 0.1-10 mg/ml, trehalose at 0.2-30 mg/ml, and dextran at 0.1-30 mg/ml, wherein the moisture content is less than 5%.
A method of forming an immunogenic composition having low hygroscopicity, comprising:
- spray drying one or more live viruses from a composition comprising mannitol at 10-150 mg/ml, cyclodextrin at 0.1-10 mg/ml, trehalose at 0.2-30 mg/ml, and dextran at 0.1-30 mg/ml to form a spray dried powder containing said one or more live viruses, wherein the moisture content is less than 5%.
An immunogenic composition having low hygroscopicity, consisting essentially of one or more live viruses in a powder formulation spray dried from a composition comprising mannitol at 10-150 mg/ml, cyclodextrin at 0.1-10 mg/ml, trehalose at 0.2-30 mg/ml, and dextran at 0.1-30 mg/ml.
Dependencies are inferred from the claim text.