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US 11,446,364 B2Granted
Stable thermolysin hydrogel
AssigneeSmith & Nephew, Inc.
InventorsLei Shi, Aleksa Jovanovic, Dennis Carson
Life of this patent
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Abstract
Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
Claims21
A hydrogel comprising:
- (a) a hydrophilic gelling agent that includes a nonionic cellulose ether;
- and
- (b) active thermolysin,
- wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months,
- wherein the hydrogel further comprises a preservative and/or is sterile,
- wherein the nonionic cellulose ether is hydroxyethylcellulose, hydroxypropylcellulose, or the combination thereof, and
- wherein the hydrogel has a viscosity of 15,000 to 100,000 cps, as measured with a Brookfield RV Viscometer, spindle 14 with small sample adapter, at 10 rpm at room temperature read at 30 seconds.
4 more elements
Dependencies are inferred from the claim text.