Therapeutic APAC molecule comprising heparin conjugated to a plasma protein

A method for the treatment of a disease or condition selected from the group consisting of:

• thrombotic complications, thrombotic complications associated with endogenous rupture of an atheromatous plaque, thrombotic complications associated with thrombolytic therapy to prevent re-occlusion, thrombotic complications associated with platelet-driven arterial thrombosis, thrombotic complications associated with vascular or microvascular injuries, thrombotic complications associated with thrombotic thrombocytopenic purpura, thrombotic complications associated with ischemia reperfusion injury, thrombotic complications associated with acute kidney injury, thrombotic complications associated with myocardial infarction, thrombotic complications associated with stroke, thrombotic complications associated with peripheral arterial occlusive disease and mesenterial ischemia and thrombotic complications associated with antithrombin (AT) deficiency;
• wherein an effective amount of a medicament comprising an anti-thrombotic molecule having enhanced antiplatelet activity comprising a human plasma protein to which there is conjugated, via a plurality of linker molecules, a plurality of heparin chains each having a MW between 10-21 KDa and further wherein the number of said heparin chains conjugated to said plasma protein is selected from the group consisting of 8, 9, 10, 11, 12, 13, 14, 15, and 16 is administered to an individual to be treated;
• further wherein:
• said plasma protein is selected from the group consisting of:
• an albumin, a globulin, a fibrinogen, serum albumin and alpha2-macroglobulin;
• said heparin is unfractionated heparin;
• each linker molecule of said plurality of linker molecules, at least when linkage of said heparin to said plasma protein is complete, is a single linker molecule that binds one molecule of heparin and further is an amine linker and so links with amino groups on said heparin and plasma protein.

A method of treatment selected from the group consisting of:

• exogenous angioplasty;
• vascular or microvascular surgery;
• arterial intervention;
• angioplasty;
• percutaneous transluminal (coronary) angioplasty with or without stenting;
• (directional) arterectomy;
• peripheral or pulmonary thrombendarterectomy;
• and exogenous interventions comprising insertion and maintenance of arterio-venous fistula or grafts;
• and the use of catheters;
• wherein an effective amount of a medicament comprising an anti-thrombotic molecule having enhanced antiplatelet activity comprising a human plasma protein to which there is conjugated, via a plurality of linker molecules, a plurality of heparin chains each having a MW between 10-21 KDa and further wherein the number of said heparin chains conjugated to said plasma protein is selected from the group consisting of 8, 9, 10, 11, 12, 13, 14, 15, and 16 is administered to an individual to be treated before, during or after said treatment;
• further wherein:
• said plasma protein is selected from the group consisting of:
• an albumin, a globulin, a fibrinogen, serum albumin and alpha2-macroglobulin;
• said heparin is unfractionated heparin;
• each linker molecule of said plurality of linker molecules, at least when linkage of said heparin to said plasma protein is complete, is a single linker molecule that binds one molecule of heparin and further is an amine linker and so links with amino groups on said heparin and plasma protein.

A medicament for treating thrombosis or suspected thrombosis, comprising an anti-thrombotic molecule having enhanced antiplatelet activity:

• wherein the anti-thrombotic molecule comprises a human plasma protein to which there is conjugated, via a plurality of linker molecules, a plurality of heparin chains each chain having a MW between 10-21 KDa and further wherein the number of said heparin chains conjugated to said plasma protein is selected from the group consisting of 8, 9, 10, 11, 12, 13, 14, 15, and 16;
• further wherein:
• said plasma protein is selected from the group consisting of:
• an albumin, a globulin, a fibrinogen, serum albumin and alpha2-macroglobulin;
• said heparin is unfractionated heparin;
• each linker molecule of said plurality of linker molecules, at least when linkage of said heparin to said plasma protein is complete, is a single linker molecule that binds one molecule of heparin and further is an amine linker and so links with amino groups on said heparin and plasma protein.