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US 11,446,357 B2Granted
Method for treating disease using FOXP3+CD4+ T cells
AssigneeKyverna Therapeutics, Inc.
InventorsAshley Mahne, John Lee, Lih-Yun Hsu, Jeffrey Greve
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Abstract
This document relates to methods and materials for treating a mammal having an autoimmune disease. For example, materials and methods for producing a T cell comprising a FOXP3 polypeptide and one or more transcription factors are provided herein. Methods and materials for treating a mammal having an autoimmune disease comprising administering to a mammal having an autoimmune disease an effective amount of a T cell are also provided herein.
Claims15
A method for increasing human T cell function, wherein the method comprises introducing into a human T cell:
- (i) a first nucleic acid sequence encoding a forkhead box P3 (FOXP3) polypeptide;
- and
- (ii) a second nucleic acid sequence encoding one or more transcription factor(s) selected from the group consisting of:
- ID2, ID3, GATA1, GATA3,)(XBP1, and SATB1,
- wherein the first nucleic acid sequence and the second nucleic acid sequence are disposed in a nucleic acid construct.
2 more elements
Dependencies are inferred from the claim text.