Bacteriotherapy for clostridium difficile colitis
AssigneeRebiotix, Inc.
InventorEdwin J. Hlavka
Life of this patent
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Abstract
This document discusses, among other things, receiving a plurality of donor fecal samples from a plurality of donors and storing and indexing each respective donor fecal samples using at least one characteristic of the respective donor fecal sample. In an example, the donor fecal sample can be screened and processed for subsequent use in fecal bacteriotherapy to displace pathogenic or undesired organisms in the digestive track of a patient with healthy or desirable gut microbiota.
Claims18
A bacteriotherapy composition in oral dosage form, comprising:
- a bacteriotherapy composition contained within an oral capsule, prepared by a process comprising:
- collecting a first fecal sample from a donor,
- processing the first fecal sample to form a first processed fecal sample, wherein processing the first fecal sample comprises homogenizing, filtering, and adding a cryoprotectant to the first fecal sample to obtain a first processed fecal sample,
- storing the first processed fecal sample in a cold storage device,
- collecting a second fecal sample from the donor,
- processing the second fecal sample to form a second processed fecal sample, wherein processing the second fecal sample comprises homogenizing, filtering, and adding a cryoprotectant to the second fecal sample to obtain a second processed fecal sample,
- storing the second processed fecal sample in a cold storage device,
- combining the first processed fecal sample with the second processed fecal sample to obtain the bacteriotherapy composition, and
- encapsulating the bacteriotherapy composition within an oral capsule.
A method for manufacturing a bacteriotherapy composition in oral dosage form, the method comprising:
- collecting a first fecal sample from a donor;
- processing the first fecal sample to form a first processed fecal sample, wherein processing the first fecal sample comprises homogenizing, filtering, and adding a cryoprotectant to the first fecal sample to obtain a first processed fecal sample;
- storing the first processed fecal sample in a cold storage device;
- collecting a second fecal sample from the donor;
- processing the second fecal sample to form a second processed fecal sample, wherein processing the second fecal sample comprises homogenizing, filtering, and adding a cryoprotectant to the first fecal sample to obtain a first processed fecal sample;
- storing the second processed fecal sample in a cold storage device;
- combining the first processed fecal sample with the second processed fecal sample to form the bacteriotherapy composition;
- and
- encapsulating the bacteriotherapy composition within an oral capsule.
An oral bacteriotherapy composition, comprising:
- an oral capsule containing a plurality of processed fecal samples from a single donor that have been individually cooled and then pooled, wherein at least one of the plurality of processed fecal samples comprises a cryoprotectant.
Dependencies are inferred from the claim text.