Compositions comprising bacterial strains
Assignee4D Pharma Research Limited
InventorsImke Elisabeth Mulder, Anna Ettorre, Suaad Ahmed, Parthena Fotiadou
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Abstract
The invention provides a composition comprising a bacterial strain of the genus Parabacteroides, for use in a method of treating or preventing cancer in a subject; wherein the cancer comprises oncogenic ERK signalling.
Claims20
A method of treating cancer in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a bacterial strain of the species Parabacteroides distasonis, wherein the bacterial strain comprises a 16s rRNA gene sequence having at least 98% sequence identity to the polynucleotide sequence of SEQ ID NO:
- 9, and wherein the cancer comprises oncogenic ERK signaling, and comprises an oncogenic mutation in, or overexpression of, BRAF, NRAS, ARAF, CRAF, EGFR, GRB2, SOS, HRAS, KRAS, MEK1, MEK2, ERK1 or ERK2.
A method of treating cancer in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a bacterial strain of the species Parabacteroides distasonis,
- wherein the bacterial strain comprises a 16s rRNA gene sequence having at least 98% sequence identity to the polynucleotide sequence of SEQ ID NO:
- 9, and wherein the cancer comprises oncogenic ERK signaling.
Dependencies are inferred from the claim text.