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US 11,446,335 B2Granted
Cryopreserved endocrine cells that express chromogranin A
AssigneeViaCyte, Inc.
InventorsAlan D. Agulnick, Kevin Allen D'Amour
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Abstract
A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
Claims12
A cryopreserved composition, comprising
- a) a population of human endocrine cells that expresses chromogranin A (CHGA), wherein the human endocrine cells mature into insulin secreting cells when thawed and transplanted into a mammalian subject;
- b) unipotent human immature beta cell suspension aggregates, wherein at least 10% of cells in the aggregates are human immature beta cells that co-express INS and NKX6.1;
- and
- c. a cryopreservative.
1 more element
Dependencies are inferred from the claim text.