US 11,446,333 B2 · Use of composition comprising stem cell-derived exosome as effective ingredient for suppression or alleviation of pruritus

Abstract

The present invention provides a composition for preventing, suppressing, alleviating, ameliorating or treating pruritus comprising stem cell-derived exosomes as an active ingredient. The composition of the present invention is able to act against pruritus-inducing multiple cytokine targets, for example, IL-4, IL-31 and TSLP, and thus is able to be widely applied against pruritus caused by various factors and is able to effectively suppress and alleviate pruritus. In addition, when the composition of the present invention is applied directly to human skin, it is able to remarkably ameliorate pruritus-associated clinical scores, erythema and the like. Thus, the composition of the present invention is able to be used as a pharmaceutical composition, a skin external preparation and a cosmetic composition for preventing, suppressing, alleviating, ameliorating or treating pruritus.

Claims18

Dependent claims

A method for suppressing, alleviating, ameliorating or treating pruritus mediated by thymic stromal lymphopoietin (TSLP) in a subject in need thereof, the method comprising:

administering an effective amount of a composition comprising exosomes as an active ingredient to the subject, said exosomes being derived from adipose-derived stem cells;
and
decreasing expression and/or production of TSLP in the subject.

Dependencies are inferred from the claim text.

Facts

Application

16/727,173Filed 26 Dec 2019 · continuation

Priority

KR 10-2017-008350830 Jun 2017

Published

US 2020/0121722 A123 Apr 2020

Granted

20 Sep 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 35/28
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…
A61K 8/98
Containing materials, or derivatives thereof of undetermined constitution: of animal origin
A61K 9/0009
Galenical forms characterised by the drug release technique; Application systems commanded by energy: involving or responsive to electricity,…
A61K 47/36
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: polysaccharides; Derivatives thereof, e.g. gums, starch, alginate,…

Use of composition comprising stem cell-derived exosome as effective ingredient for suppression or alleviation of pruritus

Life of this patent

Use of composition comprising stem cell-derived exosome as effective ingredient for suppression or alleviation of pruritus

Life of this patent

Abstract

Claims18