Antibodies against N-acetylglucosamine and N-acetyl-galactosamine
AssigneeB&H Biotechnologies, LLC
InventorHuiru Wang
Life of this patent
Estimating the term…
Abstract
It provides antibodies and chimeric antigen receptors (CARs) that specifically bind to an epitope containing N-acetyl-glucosamine and/or N-acetyl-galactosamine, e.g., expressed by a cancer cell or an inflammatory cell. Also provided are compositions including these antibodies and/or CARs, as well as polynucleotides, vectors, host cells, methods, and kits related thereto. Further provided are methods and kits for treating or preventing cancer in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, or a T cell comprising a CAR that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, optionally in combination with another anti-cancer agent.
Claims18
An isolated monoclonal antibody that specifically binds to an epitope comprising N-acetylglucosamine or N-acetyl-galactosamine, wherein the antibody comprises a light chain variable region comprising an HVR-L1 sequence of SEQ ID NO:
- 5, an HVR-L2 sequence of FTSX1LX2S (SEQ ID NO:
- 25), and an HVR-L3 sequence of SEQ ID NO:
- 9, wherein X1 is T or S and X2 is Q or E, and wherein the antibody comprises a heavy chain variable region comprising an HVR-H1 sequence of SEQ ID NO:
- 1, an HVR-H2 sequence of SEQ ID NO:
- 2, and an HVR-H3 sequence of SEQ ID NO:
- 3.
A chimeric antigen receptor (CAR) that specifically binds to an epitope comprising N-acetylglucosamine or N-acetyl-galactosamine, wherein the CAR comprises a light chain variable region comprising an HVR-L 1 sequence of SEQ ID NO:
- 5, an HVR-L2 sequence of FTSX1LX2S (SEQ ID NO:
- 25), and an HVR-L3 sequence of SEQ ID NO:
- 9, wherein X1 is T or S and X2 is Q or E and a heavy chain variable region comprising an HVR-H1 sequence of SEQ ID NO:
- 1, an HVR-H2 sequence of SEQ ID NO:
- 2, and an HVR-H3 sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.