Compositions and methods for the treatment of fibrotic diseases

A method of treating a disease associated with fibrosis in an organ or tissue of the subject selected from the group consisting of kidney, lung, liver, skin, bone, bone marrow, an endocrine organ and an organ of the gastrointestinal system, in need thereof comprising administering to the subject a therapeutically effective amount of miRNA-423-5p and at least one miRNA selected from the group consisting of hsa-miR-452-3p, hsa-miR-224-3p, hsa-miR-378i, hsa-miR-10b-5p, hsa-miR-99a-3p, hsa-miR-105-3p, hsa-miR-224-5p, hsa-miR-10b-3p, hsa-miR-338-5p, hsa-miR-767-5p, hsa-miR-196b-5p, hsa-miR-148a-3p, hsa-miR-452-5p, hsa-miR-873-5p, hsa-miR-873-3p, hsa-let-7a-3p, hsa-miR-208b-3p, hsa-miR-582-3p, hsa-miR-196a-5p, hsa-miR-99b-3p, hsa-miR-320d, hsa-let-7e-3p, hsa-miR-378a-3p, hsa-miR-183-5p, hsa-miR-532-5p, mir18, hsa-miR-3529-3p, hsa-miR-3074-5p, hsa-let-7f-1-3p, hsa-let-7c-3p, hsa-miR-378c, hsa-miR-486-5p, hsa-miR-185-3p, hsa-miR-320e, hsa-miR-182-5p, mir78, hsa-miR-340-3p, hsa-miR-24-2-5p, hsa-miR-330-3p, hsa-miR-192-3p, hsa-miR-26a-2-3p, hsa-miR-26b-3p, hsa-miR-99a-5p, hsa-miR-148b-3p, hsa-miR-374a-3p, hsa-miR-30a-3p, mir32, hsa-miR-17-3p, hsa-miR-193b-5p, hsa-let-7i-5p and hsa-miR-19b-3p, thereby treating the disease associated with fibrosis.