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US 11,446,310 B2Granted
Stable formulations for parenteral injection of small molecule drugs
AssigneeXeris Pharmaceuticals, Inc.
InventorsSteven J. Prestrelski, Nancy Scott
Life of this patent
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Abstract
Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 μl to 3 ml.
Claims21
A stable liquid formulation for parenteral injection comprising:
- (a) a biocompatible non-aqueous aprotic solvent, wherein the non-aqueous aprotic solvent is dimethylsulfoxide (DMSO), dimethylformamide (DMF), ethyl acetate, n-methyl pyrrolidone (NMP), dimethyl acetamide (DMA), propylene carbonate, or mixtures thereof;
- and
- (b) a small molecule drug, or a salt thereof, solubilized within the solvent, wherein the small molecule drug is selected from a catecholamine or a triptan, wherein the small molecule drug is present in the liquid formulation in an amount up to its solubility limit in the formulation;
- wherein the liquid formulation comprises less than 5% by weight residual water;
- and
- wherein the volume of the liquid formulation to be parenterally injected is 3 ml or less.
3 more elements
Dependencies are inferred from the claim text.