Bicyclic bromodomain inhibitors

A compound of Formula IIc′″:

• or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof, wherein:
• the A-B bicyclic ring is optionally substituted with one or more groups independently selected from deuterium, —NH2, amino, heterocycle(C4-C6), carbocycle(C4-C6), halogen, —CN, —OH, —CF3, alkyl(C1-C6), thioalkyl(C1-C6), alkenyl(C1-C6), and alkoxy(C1-C6);
• D1 is
• X is selected from —CH2— and —CH(CH3)—;
• and
• R4 is a phenyl ring optionally substituted with groups independently selected from deuterium, alkyl(C1-C4), alkoxy(C1-C4), halogen, —CF3, CN, and -thioalkyl(C1-C4), wherein each alkyl, alkoxy, and thioalkyl may be optionally substituted with F, Cl, or Br.