Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions
AssigneeTosk, Inc.
InventorsWilliam A. Garland, Heshan Peiris, Philip Liaw, Brian D. Frenzel
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Abstract
Methods of treating a subject for a liver condition, e.g., NAFLD, NASH, and/or DILI, are provided. Aspects of the methods include administering to the subject an effective amount of a UPase inhibitor, optionally in combination with a uridine active agent (e.g., uridine (UR), a UR pro-drug or a UR mimetic), such as supplemental uridine, to treat the subject for the liver condition. Also provided are compositions for use in practicing the subject methods.
Claims18
A method of treating a subject for a liver condition selected from the group consisting of NAFLD and NASH, the method comprising:
- administering to the subject an effective amount of a 2,2′-anhydropyrimidine or derivative thereof to ameliorate fibrosis to treat the subject for the liver condition, wherein the subject suffers from the liver condition.
A method of treating a subject for a liver condition selected from the group consisting of NAFLD and NASH, the method comprising:
- administering to the subject an effective amount of a 2,2′-anhydropyrimidine or derivative thereof in combination with a uridine (UR) active agent to ameliorate fibrosis to treat the subject for the liver condition, wherein the subject suffers from the liver condition.
Dependencies are inferred from the claim text.