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US 11,446,301 B2Granted
Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
AssigneeNanjing Zhengxiang Pharmaceuticals Co., Ltd.
InventorXiaolin Hao
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Abstract
The present disclosure provides selective phosphoinositide 3-kinase inhibitors of formula (A), or pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of conditions mediated by one or more P13K isoforms, such as PI3K delta (PI3Kδ). The present disclosure further provides methods of inhibiting phosphoinositide 3-kinase inhibitors using these compounds for treatment of disorders related to phosphatidylinositol 3-kinase activity.
Claims20
A compound having a structure of formula (A), or a pharmaceutically acceptable salt, or solvate thereof:
- wherein X is selected from the group consisting of N or CH;
- each R1 and R2 is independently selected from the group consisting of H, F, and SO2Me, and
- R3 is F.
Dependencies are inferred from the claim text.