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US 11,446,290 B2Granted
Treatment of pain with serotonin-3 receptor agonist
AssigneeOsaka University
InventorsShoichi Shimada, Yukiko Yamamoto, Makoto Kondo
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AssigneeOsaka University
InventorsShoichi Shimada, Yukiko Yamamoto, Makoto Kondo
Estimating the term…
The present invention provides a drug for preventing or treating chronic pain and a method for preventing or treating chronic pain. A pharmaceutical composition comprising a serotonin-3 receptor agonist such as a compound represented by the following formula (I): [wherein: m is an integer of 1 to 4; and R1 is each independently selected from the group consisting of a hydrogen atom, a halogen atom, a methyl group optionally substituted with 1 to 3 halogen atom(s), a methoxy group optionally substituted with 1 to 3 halogen atom(s), and a methylthio group optionally substituted with 1 to 3 halogen atom(s)] or a pharmaceutically acceptable salt thereof is useful for preventing or treating chronic pain. The above pharmaceutical composition is also useful for preventing or treating acute pain. Further, the present invention provides a method for screening a compound for preventing or treating chronic pain, the method comprising measuring a serotonin-3 receptor agonist activity.
A method for treating chronic pain, the method comprising subcutaneously, intravenously, intraperitoneally, intramuscularly, intrarectally, or orally administering to a patient an effective amount of a serotonin-3 receptor agonist and a pharmaceutically acceptable carrier,
Dependencies are inferred from the claim text.