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US 11,446,289 B2Granted
Combination therapy using C-C chemokine receptor 4 (CCR4) antagonists and one or more immune checkpoint inhibitors
AssigneeChemoCentryx, Inc.
InventorsShijie Li, Venkat Reddy Mali, Rajinder Singh, Ju Yang, Penglie Zhang
Life of this patent
Estimating the term…
Abstract
The present disclosure is drawn to the combination therapy of a C—C Chemokine Receptor 4 (CCR4) antagonist and one or more immune checkpoint inhibitors in the treatment of cancer.
Claims14
A method of treating colon cancer or pancreatic cancer in a mammal, said method comprising administering an effective amount of a C—C Chemokine Receptor 4 (CCR4) antagonist and a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor,
- wherein the CCR4 antagonist has the formula selected from the group consisting of
Dependencies are inferred from the claim text.