Compounds and methods for the treatment of microbial infections
AssigneeVersitech Limited
InventorsYi Tsun Richard Kao, Peng Gao, Xuechen Li, Ming Liu
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Abstract
Provided herein are compounds, derivatives thereof, and compositions including one or more of the compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, the microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections.
Claims10
A compound having one of the following formulae:
A method of treating and/or preventing microbial infections in a subject comprising:
- administering to said subject an effective amount of a compound of formula (I) or a derivative thereof:
- wherein R1, R2, and R3 are independently or jointly selected from the group consisting of:
- H;
- I;
- OH;
- CN;
- (C1-4)alkyl;
- (C2-4)alkenyl, wherein a double bond is optionally located at any position in the alkenyl carbon chain;
- alkynyl;
- aralkyl;
- alkaryl;
- halogenated alkyl;
- aryl;
- heterocyclyl;
- cycloalkyl;
- cycloalkenyl;
- cycloalkynyl;
- hydroxyalkyl;
- aminoalkyl;
- acylamino;
- thiol;
- thioalkyl;
- alkoxy;
- alkoxyalkyl;
- aryloxy;
- arylalkoxy;
- acyloxy;
- carbamoyl;
- trifluoromethyl;
- phenoxy;
- benzyloxy;
- phosphonic acid;
- phosphate ester;
- sulfonic acid (—SO3H);
- sulfonate ester;
- sulfonamide;
- carbamate;
- alkyltriphenylphosphonium;
- ketone (═O);
- ether (—OR4);
- ester (—COOR5 and —OC(═O)R5), and R1 is not methyl at a C-2 position or a C-4 position in a cyclic group when R2 and R3 are both H,
- wherein R1, R2, and R3 are not jointly H;
- R3 is not methyl when R1 and R2 are both H;
- R1 and R2 are not jointly —OMe, or
- wherein R1 R2 are optionally bonded together to form a four-, five-, or six-membered heterocyclyl, cycloalkenyl, or cycloalkyl, and wherein R1 and R2 are not bonded together to form
- and
- wherein R4 and R5 are independently or jointly selected from the group consisting of:
- a (C1-4)alkyl;
- (C2-4)alkenyl, wherein a double bond is optionally located at any position in the alkenyl carbon chain;
- and alkynyl, and wherein R4 is not methyl when R2 and R3 are both H.
Dependencies are inferred from the claim text.