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US 11,446,269 B2Granted
Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorRichard Preston Mason
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Abstract
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing or preventing small dense LDL (“sdLDL”) oxidation in a subject, the method comprising administering to the subject a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Claims5
A method of treating a cardiovascular-related disease in a subject having glucose levels of at least about 200 mg/dL, the method comprising:
- (a) measuring a baseline level of membrane cholesterol domain formation and a baseline level of oxidative modification of membrane polyunsaturated fatty acids in the subject prior to step (b);
- and
- (b) administering to the subject a pharmaceutical composition comprising at least 80%, by weight of all fatty acids (and/or derivatives thereof) that are present in the composition, eicosapentaenoic acid or a derivative thereof,
- wherein the administering to the subject the pharmaceutical composition reduces the membrane cholesterol domain formation in the subject by between 10% and 100% compared to the baseline level, and
- wherein the administering to the subject the pharmaceutical composition reduces the oxidative modification of membrane polyunsaturated fatty acids in the subject by between 10% and 100% compared to the baseline level.
2 more elements
Dependencies are inferred from the claim text.