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US 11,446,260 B2Granted
Pharmaceutical composition of S-ketamine hydrochloride
AssigneeJanssen Pharmaceutica NV
InventorsEsther D. G. Basstanie, Johanna Bentz, Roger C. A Embrechts, Nico Rudolph Niemeijer
Life of this patent
Estimating the term…
Abstract
The present invention is directed to an aqueous formulation of S-ketamine hydrochloride, preferably for nasal administration, wherein the formulation does not contain an antimicrobial preservative.
Claims75
A method comprising:
- intranasally administering to a human patient a pharmaceutical composition comprising (S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride and water;
- wherein the (S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride is present in a concentration in the range of from about eq. 120 mg/mL to about eq. 250 mg/mL, based on the total volume of the pharmaceutical composition;
- wherein the pharmaceutical composition is administered as clusters of from 2 and up to 8 consecutive sprays within a time period of up to about 60 minutes, and
- wherein the patient is in need of treatment for depression, wherein the depression is major depressive disorder, and a therapeutically effective amount of the pharmaceutical composition is administered to alleviate one or more symptoms of the depression.
1 more element
A method comprising:
- intranasally administering to a human patient a pharmaceutical composition comprising (S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride and water;
- wherein the (S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride is present in a concentration in the range of from about 126 mg/mL to about 250 mg/mL, based on the total volume of the pharmaceutical composition;
- wherein the pharmaceutical composition is administered as clusters of from 2 and up to 8 consecutive sprays within a time period of up to about 60 minutes, and
- wherein the patient is in need of treatment for depression, wherein the depression is major depressive disorder, and a therapeutically effective amount of the pharmaceutical composition is administered to alleviate one or more symptoms of the depression.
1 more element
Dependencies are inferred from the claim text.