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US 11,446,254 B2Granted
Drug carrier having self-assembled 3-D nucleic acid nanostructure
AssigneeKorea Institute of Science and Technology
InventorsDae Ro Ahn, Se Hoon Kim, Kyoung Ran Kim, Hyo Young Kim, Yong Deok Lee
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Abstract
The present invention relates to a molecule delivery technology and a carrier technology, which may selectively deliver a material to a desired specific cell and living tissue. The present invention may be utilized in the field of a drug carrier which effectively delivers an imaging probe and a therapeutic agent to an affected part.
Claims9
A method of in vivo delivering a pharmaceutically active ingredient to cancer tissue, comprising:
- administering a self-assembled 3-D nucleic acid nanostructure as a pharmaceutically active ingredient carrier to a subject in need thereof,
- wherein the self-assembled 3-D nucleic acid nanostructure comprises:
- double strand nucleic acids;
- and
- single strands form the sides of the self-assembled 3-D nucleic acid nanostructure,
- wherein the pharmaceutically active ingredient carrier has an L-DNA triangular prism structure composed of 5 strands of L-DNA self-assembled from the combination of:
- i) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:15;
- ii) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:16;
- iii) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:17;
- iv) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:18;
- and
- v) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:19, and
- wherein the pharmaceutically active ingredient carrier does not comprise a targeting ligand for the tissue.
10 more elements
A method of in vivo delivering an anticancer agent comprising:
- administering a pharmaceutical composition comprising:
- a self-assembled 3-D nucleic acid nanostructure as an anticancer agent carrier to carry the anticancer agent to a subject in need thereof,
- wherein the self-assembled 3-D nucleic acid nanostructure comprises:
- double strand nucleic acids;
- and
- single strands form the sides of the self-assembled 3-D nucleic acid nanostructure,
- wherein the anticancer agent carrier has an L-DNA triangular prism structure composed of 5 strands of L-DNA self-assembled from the combination of:
- i) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:15;
- ii) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:16;
- iii) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:17;
- iv) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:18;
- and
- v) a single strand of an L-DNA nucleotide sequence of SEQ ID NO:19, and
- wherein the anticancer agent carrier does not comprise a targeting ligand for the tissue.
11 more elements
Dependencies are inferred from the claim text.