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US 11,446,249 B2Granted
Viral vector stabilization
AssigneeTrizell Ltd.
InventorsMinna Hassinen, Robert Shaw, Nigel Parker
Life of this patent
Estimating the term…
Abstract
Combining viral vector with surfactant preserves vector infectivity, and surfactant provided an unexpected benefit by protecting viral vector from damage due to transient elevated temperature.
Claims8
A method of preserving the infectivity of a recombinant adenovirus, comprising:
- mixing the recombinant adenovirus comprising a transgene and having infectivity with a surfactant to form an admixture;
- removing substantially all water from the admixture, and storing the admixture at or about 4° C. or room temperature for at least about one week, wherein after the storing step the adenovirus retains a higher level of infectivity relative to control, and wherein the surfactant has Structure I:
Dependencies are inferred from the claim text.