Liposome composition and pharmaceutical composition
AssigneeFUJIFILM Corporation
InventorsNoriyuki Kasagi, Naoki Yamada, Mikinaga Mori, Takayuki Kato, Takayuki Kobayashi
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Abstract
An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.
Claims15
A liposome composition comprising:
- liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed,
- wherein the liposomes comprise
- a hydrophilic polymer-modified diacylphosphatidylethanolamine,
- a dihydrosphingomyelin, and cholesterols
- wherein each of the liposomes encapsulates a drug,
- the inner water phase contains ammonium sulfate,
- and the molar ratio of sulfate ions in the inner water phase to the sum of the drug contained in the inner water phase and the outer water phase is 0.6 or more and 1.8 or less.
Dependencies are inferred from the claim text.