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US 11,446,246 B2Granted
Suspensions and diluents for metronidazole and baclofen
AssigneeAzurity Pharmaceuticals, Inc.
InventorsKen Fallin, Zeus Pendon, Priya Capila, Neal Muni
Life of this patent
Estimating the term…
Abstract
Suspensions of metronidazole or baclofen and/or salts or ester derivative thereof, such as metronidazole benzoate, are disclosed. The suspension my include metronidazole or baclofen, and/or a salt or ester derivative thereof a hydrocolloid stabilizer, simethicone emulsion, a buffer, such as sodium citrate, (dihydrate), a preservative, a thickening agent, a sweetener, and water.
Claims16
A method of treating spasticity in a subject comprising administering to the subject a liquid oral pharmaceutical composition, wherein the liquid oral pharmaceutical composition comprises:
- a) 5 mg/ml of baclofen or a salt thereof;
- b) 0.12% (w/v) of citric acid (anhydrous);
- c) 0.5% (w/v) of hydroxyethyl cellulose;
- d) 5% (w/v) of propylene glycol;
- e) 0.15% (w/v) of simethicone emulsion (30%);
- f) 0.1% (w/v) of sodium benzoate;
- g) 0.2% (w/v) of sucralose;
- and
- h) water,
- wherein a pH of the liquid oral pharmaceutical composition is between 3.0 and 6.0, and
- wherein the liquid oral pharmaceutical composition retains less than +/−5% variation of baclofen concentration measured by a USP assay for at least 30 days when stored at room temperature.
8 more elements
Dependencies are inferred from the claim text.