US 11,446,242 B2 · Suspension component-specific triamcinolone and moxifloxacin compositions and associated methods of use

Abstract

Provided here are new ophthalmologically suitable pharmaceutical compositions comprising an effective amount of a moxifloxacin compound and an effective amount of a triamcinolone compound and a suspension component comprising a polysorbate, hyaluronic acid, or both. In aspects, the compositions are stable suspensions maintaining physical stability and chemical stability for extended periods of time (e.g., exhibiting no sustained flocculation, coagulation, or clumping after several months of storage under typical storage conditions). In aspects, the compositions comprise a non-ionic surfactant or, e.g., a non-ionic suspension agent providing both surfactant and suspension functionality. In aspects, such compositions further comprise an effective amount of a chelating agent/component. Further described are related compositions and methods of making and using such compositions, e.g., in the treatment of eye infections.

Claims33

Dependent claims

An ophthalmologically suitable pharmaceutical composition in the form of a suspension comprising:

(a) an effective amount of at least one ionic suspension agent wherein the at least one ionic suspension agent is at least mostly composed of a hyaluronic acid component;
(b) an effective amount of at least one non-ionic suspension agent, wherein at least one non-ionic suspension agent is also a non-ionic surfactant at least mostly composed of a polysorbate;
and (c) at least two pharmaceutical ingredients comprising (1) moxifloxacin or a pharmaceutically acceptable salt thereof in a range of about 0.01% to about 0.5% by weight, and (2) triamcinolone or a pharmaceutically acceptable salt thereof in a range of about 0.1% to about 5% by weight, wherein the composition is free of an effective amount of any non-ionic polyoxyethylene-polyoxypropylene block copolymer having the following chemical structure —HO—(CH2-CH2-O)x-(C3H6-O)y-(CH2-CH2-O)x-H, wherein x is an integer having a value of at least 8 and y is an integer having a value of at least 38.

Dependencies are inferred from the claim text.

Suspension component-specific triamcinolone and moxifloxacin compositions and associated methods of use

Life of this patent

Suspension component-specific triamcinolone and moxifloxacin compositions and associated methods of use

Life of this patent

Abstract

Claims33