Injectable dendrimer hydrogel nanoparticles

A method of reducing, or preventing inflammation comprising administering an effective amount of a composition comprising a poly(amidoamine) (PAMAM) dendrimer covalently conjugated via terminal functional groups to amino acid linkers,

• wherein the terminal functional groups of the dendrimer are selected from the group consisting of amine, carboxylic acid, and hydroxyl groups,
• wherein some of the amino acid linkers conjugated to the dendrimer are covalently bound to one chemically reactive group and some of the amino acid linkers are covalently bound to a different chemically reactive group,
• wherein each of the chemical reactive groups is conjugated to a drug selected from the group consisting of N-acetyl cysteine, non-steroidal antiinflammatories, and corticosteroids.

A method of reducing or preventing microbial growth in a subject in need thereof comprising administering an effective amount of a composition comprising a poly(amidoamine) (PAMAM) dendrimer covalently conjugated via terminal functional groups to amino acid linkers,

• wherein the terminal functional groups of the dendrimer are selected from the group consisting of amine, carboxylic acid, and hydroxyl groups,
• wherein some of the amino acid linkers conjugated to the dendrimer are covalently bound to one chemically reactive group and some of the amino acid linkers are covalently bound to a different chemically reactive group,
• wherein each of the chemical reactive groups is conjugated to a drug selected from the group consisting of macrolide antibiotics, tetracyclines, fluoroquinolones, cephalosporins and pharmaceutically acceptable salts thereof.