Topical antimicrobial compositions and methods of formulating the same

A method of treating a bacterial infection of a subject, the method comprising:

• topically administering a topical composition to the subject comprising contacting an infected tissue surface of the subject to be treated with the topical composition,
• wherein the tissue surface comprises skin or mucosal tissue of a vagina or anus,
• wherein the topical composition comprises nitrofurantoin, carboxymethylcellulose sodium, anhydrous citric acid, glycerin, magnesium aluminum silicate, methylparaben, flavoring, propylparaben, purified water, saccharin sodium, sodium citrate, sorbitol, and a keratolytic agent selected form urea, salicylic acid, papain, or combinations thereof, and
• wherein the topical composition is administered to the tissue surface in a dosage amount of between approximately 25 mg and approximately 200 mg nitrofurantoin.