Skin care compositions and methods of use thereof

A method for tightening and firming sagging or loose skin, managing or controlling or reducing or preventing the effect of skin aging, improving skin tone, improving skin elasticity, smoothing or toning skin, promoting skin rejuvenation, reducing water retention for smoother and tighter skin, protecting against free radical damage, reducing fat synthesis, reducing fat content in cells, reducing fat cell size, reducing or inhibiting cell differentiation into fat cells, promoting fat cell apoptosis, promoting lipolysis, improving fat removal, maintaining or promoting or supporting a healthy lipid profile, maintaining or promoting or supporting a healthy cholesterol level, or any combination thereof, comprising administering an effective amount of a composition comprising one or more acetogenins having a structure according to formula (A) as follows:

• (A)R1-L-R2-R3
• wherein R1 is a linear C5-20 optionally substituted with 0 to 10 —OH, —C(═O)Rg, —C(═O)ORg, and containing from 0 to 2 double bonds;
• wherein Rg is the same or different and independently hydrogen or C1-5 alkyl;
• wherein L is a group selected from a tetrahydrofuran group of structure (B), an epoxy group of structure (C), a heterocycle group of structure (D), CC1-5 alkyl, a
• or a group of formula L1-(X-L2)p, wherein L1 and L2 are independently selected from a tetrahydrofuran group of structure (B), an epoxy group of structure (C), a heterocycle group of structure (D), C1-5 alkyl, and a
• wherein R is H or —OH, and X is a C0-5 alkyl optionally substituted with —OH;
• wherein R2 is a linear C5-20 optionally hyrdroxylated or carboxylated and containing from 0 to 2 double bonds;
• wherein R3 is a lactone moiety selected from
• cis or trans
• wherein in R9 and R10 are independently H or —OH.