Methods, devices, and systems for improving skin characteristics
AssigneeZeltiq Aesthetics, Inc.
InventorsJoel N. Jimenez Lozano, Like Zeng, Linda Pham, George Frangineas, Jr.
Life of this patent
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Abstract
Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.
Claims16
A method of improving one or more skin characteristics in a subject comprising:
- cooling the subject's skin at a target site with a treatment unit to lower the temperature of the epidermis at the target site to about −15° C. to about 5° C., and
- discontinuing cooling when the temperature of the epidermis at the target site has been at a temperature of about −15° C. to about 5° C. for about 10 minutes to about 25 minutes such that adipocyte signaling is altered but less than 10% of subcutaneous lipid-rich cells are destroyed, wherein said alteration of adipocyte signaling produces an improvement in one or more skin characteristics.
A method of improving one or more skin characteristics in a subject comprising:
- applying a cooling element proximal to a target site on the subject's skin for a period of time sufficient to cool the epidermis at the target site to about −15° C. to about 5° C., wherein said cooling results in an alteration of one or more adipocyte signaling events;
- and
- removing the cooling element before the temperature of the subcutaneous fat layer about 7 mm below the target site decreases below a temperature of 3° C.
Dependencies are inferred from the claim text.