Method and apparatus for extracting and delivery of entities

A method of obtaining a first entity from a target site of an object or delivering a second entity to the target site of the object, the method comprising:

• placing a device at the target site, the device comprising:
• a conduit having an outer surface, a proximal end and a distal end, the distal end having an aperture that is disposed at the target site of the object for obtaining the first entity therefrom or delivering the second entity thereto during use;
• a displacement signal source disposed near the proximal end of the conduit, the displacement signal source being configured to generate acoustic or mechanical waves having at least one frequency, wherein the acoustic or mechanical waves are converted to a mechanical displacement signal along the conduit;
• a coupling assembly for coupling the displacement signal source to the conduit at a coupling location and a coupling angle at a portion of the conduit, the coupling assembly including a waveguide having a length and a width with the length being greater than the width and the waveguide being configured to guide the acoustic or mechanical waves in a longitudinal direction of the waveguide from the displacement signal source to the conduit during use;
• a pressure controller coupled to the proximal end of the conduit for varying an amount of pressure therein for delivery of the second entity or acquiring of the first entity;
• and
• a control unit coupled to the displacement signal source for controlling the displacement signal source;
• selecting the at least one frequency of the generated acoustic of mechanical waves based on the coupling location and the coupling angle between the coupling assembly and the conduit to provide a desired acoustic or mechanical wave mode at a portion of the conduit to provide controlled movement for at least one of an end region of the conduit and a tip of the conduit when obtaining the first entity from the target site or delivering the second entity to the target site;
• and
• generating the mechanical displacement signal using the displacement signal source to obtain the first entity from the target site or deliver the second entity to the target site.