Sample collection and preservation devices, systems and methods

A method for monitoring a health condition of a subject, said method comprising:

• (a) using a sample collector to non-invasively collect a vaginal biological sample from a vaginal canal of said subject, wherein said sample collector collects and retains said vaginal biological sample from said vaginal canal;
• (b) receiving said sample collector in an extractor comprising (i) a first chamber configured to receive said sample collector via an opening, (ii) a second chamber in fluid communication with said first chamber, wherein said first chamber and said second chamber are separate such that said sample collector is retained in said first chamber subsequent to deposition in said first chamber, (iii) a breakable reagent compartment comprising a solution, and (iv) an extractor top;
• (c) closing said extractor top, wherein the closing is configured to create a compression force to break the breakable reagent compartment and release said solution, thereby contacting said solution with said vaginal biological sample to form a mixture of said solution and said vaginal biological sample, wherein said mixture is received in said second chamber, and wherein said vaginal biological sample is preserved or stored by said solution in said second chamber, and wherein said mixture is free to flow between said first chamber, said second chamber, and said sample collector after said reagent compartment is broken;
• and
• (d) subsequent to (c), detecting a presence, an absence, or a change in expression level or nucleotide sequence of, a biomarker in said vaginal biological sample to determine said health condition.