Ultrasound imaging of biomarker sensitive hydrogels

A system for identifying one or more changes in a biomarker sensitive hydrogel configured to be positioned within an in vivo environment, the system comprising:

• a biomarker sensitive hydrogel, the biomarker sensitive hydrogel being configured to be positioned within the in vivo environment and configured to dimensionally change in response to interaction with one or more predefined biomarkers, wherein the biomarker sensitive hydrogel is unconstrained so as to be configured to resonate;
• an ultrasound transducer configured to locate the biomarker sensitive hydrogel within the in vivo environment and configured to identify a shift in acoustic resonance frequency of the biomarker sensitive hydrogel;
• a computer system in electrical communication with the ultrasound transducer, the computer system having one or more processors and being configured to:
• receive, from the ultrasound transducer, data relative to the acoustic resonance frequency of the biomarker sensitive hydrogel;
• and
• determine, at the one or more processors, one or more changes of the biomarker sensitive hydrogel based on the received data.