PEDOT/CNT coated neural recording probes for measurement of tonic and phasic dopamine
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsXinyan Cui, Ian Mitchell Taylor
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Abstract
Disclosed herein is a method of determining dopamine concentration at a target location in neural tissue. In several embodiments, the method comprises measuring current level in response to square wave voltammetry with a coated electrode of a neural probe implanted at the target location, wherein the coated electrode comprises a coating of poly 3,4 ethylene dioxythiophene (PEDOT) doped with negatively charged carbon nanotubes (CNT), and comparing the measured current level to a control current level to determine the dopamine concentration at the target location.
Claims18
A method for determining dopamine concentration at a target location in neural tissue, comprising:
- measuring current level in response to square wave voltammetry with a coated electrode of a neural probe implanted at the target location, wherein the target location is selected from the group consisting of the dorsal striatum, the nucleus accumbens core, the nucleus accumbens shell, the prefrontal cortex, and the amygdala, wherein the coated electrode comprises a coating of poly 3,4 ethylene dioxythiophene (PEDOT) doped with negatively charged carbon nanotubes (CNT);
- and
- comparing the measured current level to a control current level to determine the dopamine concentration at the target location.
A method for determining dopamine concentration at a target location in neural tissue, comprising:
- measuring current level in response to square wave voltammetry with a coated electrode of a neural probe implanted at the target location, wherein the coated electrode comprises a coating of poly 3,4 ethylene dioxythiophene (PEDOT) doped with negatively charged carbon nanotubes (CNT) that is electrodeposited onto the electrode with from about 5 to about 200 mC/cm2;
- and
- comparing the measured current level to a control current level to determine the dopamine concentration at the target location.
Dependencies are inferred from the claim text.