A method for an in-vivo device, the in-vivo device comprising a battery, a controller, a pixel array operable in a superpixel readout mode of operation to capture probe images by reading clusters of pixels, and in a single pixel readout mode of operation to capture normal images by reading pixels individually, the method comprising:
- causing by the controller, (i) operating the pixel array in the superpixel readout mode to capture a probe image and refraining from transmitting the probe image to save battery energy, wherein operating the pixel array in the superpixel readout mode comprises selecting a pixel binning scheme adapted to or optimized for an image parameter or image feature to be used for comparing probe images;
- (ii) in a case where at least one of the image parameter or the image feature related to the captured probe image(s) do not indicate an event of interest, repeating steps (i)-(ii);
- (iii) in a case where at least one of the image parameter or the image feature related to the captured probe image(s) indicate an event of interest, operating the pixel array in the single pixel readout mode and capturing and transmitting a normal image or a burst of normal images, and repeating steps (i)-(iii), wherein the superpixel readout mode includes clustering adjacent pixels in the pixel array to superpixels, and reading each particular superpixel of a cluster by reading one superpixel signal that represents an entire cluster of adjacent pixels of a particular superpixel;
- and further comprising calculating a score indicative of an event of interest for each probe image, and performing, for each currently captured probe image, (iv) in a case where the score of the currently captured probe image, individually or in comparison to scores of previously captured probe image, does not indicate an event of interest, capturing a subsequent probe image, refraining from transmitting the subsequent probe image and accessing the score for the subsequent probe image;
- and (v) in a case where the score of the currently captured probe image, individually or in comparison to scores of previously captured probe image, indicates an event of interest, capturing a normal image or a burst of normal images by operating the pixels in the single pixel readout mode, transmitting the normal image or the burst of normal images, capturing a subsequent probe image and repeating steps (iv)-(v);
- and (vi) calculating a difference score between the score of a currently captured probe image and the score of a previously captured probe image, wherein a score of each probe image equal to or greater than a first threshold and a difference score equal to or greater than a second threshold indicate an event of interest.