# US 11,444,646 B1 · Physiological signal acquisition system and method with improved noise and common mode rejection performance and signal quality > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,444,646 B1 - Document ID: US11444646B1 - Status: Granted - Kind: B1 - Application number: 14/986,006 - Filed: 2015-12-31 - Granted: 2022-09-13 - Earliest claimed: 2015-12-31 - Assignees: NeuroWave Systems Inc. - Applicants: Sankar Barua - Inventors: Sankar Barua - Web page: https://patentgrep.com/patent/US11444646B1 ## CPC - H04B 1/1638: {Special circuits to enhance selectivity of receivers not otherwise provided for (resonant circuits H03H)} - A61B 5/291: for electroencephalography [EEG] - A61B 5/293: Invasive - A61B 5/316: Modalities, i.e. specific diagnostic methods - A61B 5/374: Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves - A61B 5/7203: {for noise prevention, reduction or removal} - A61B 2562/222: Electrical cables or leads therefor, e.g. coaxial cables or ribbon cables - H04B: TRANSMISSION - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract The present invention relates to the acquisition, processing, and monitoring of signals, and particularly to the acquisition, processing, and monitoring of electrophysiological signals. More particularly, the present invention relates to the acquisition, processing, and monitoring electroencephalography (EEG) signals representing cortical/brain activity. Further, the present invention relates to a method and apparatus for acquiring such signals in the presence of electrical interference and noise. More particularly, the present invention relates to systems and methods for filtering out and rejecting electrical interference and noise while maintaining or improving the quality of the underlying physiological signal and preventing perturbation or introduction of artifacts into the physiological signal. ## Claims ### Claim 1 A system for an EEG physiological signal acquisition with analog front-end circuitry comprising: at least two inputs for inputting an EEG physiological signal; at least two bootstrapped filters, each bootstrapped filter comprising a resistor, a first capacitor and a second capacitor, and a unity gain buffer, the resistor and first capacitor forming a low-pass filter and the second capacitor is driven to have substantially the same upper and lower alternating current (AC) voltage as when the EEG physiological signal enters the input, the second capacitor being driven by a common mode signal or a physiological signal potential; and at least one instrumentation amplifiers, each of the at least one instrumentation amplifier comprising at least two amplifiers; wherein each of the two bootstrapped filters is directly connected to a common node of the at least two amplifiers of the instrumentation amplifier, the bootstrap filter being external to the instrumentation amplifier and adapted to remove common mode signal from the physiological signal prior to the signal entering the instrumentation amplifier and the system is adapted to have a common mode rejection ratio of 95 or greater dB. ### Claim 2 (depends on 1) The system of claim 1, further comprising at least two electrodes and leads for each electrode. ### Claim 3 (depends on 2) The system of claim 2, wherein the leads each comprise a shield adapted to shield the leads from outside electrical interference. ### Claim 4 (depends on 1) The system of claim 1, wherein the system further comprises a processor, and EEG signals are transmitted from the instrumentation amplifier to the processor which is adapted to analyze the EEG signal and to calculate a quantitative EEG (QEEG) index corresponding to a subject's brain or cortical activity level. ### Claim 5 (depends on 1) The system of claim 1, wherein the system further contains software or embedded algorithms that automatically identify artifacts and remove the artifacts from the physiological signal. ### Claim 6 A system for an EEG physiological signal acquisition with analog front-end circuitry comprising: at least two bootstrapped filters each comprising a resistor, a first capacitor and a second capacitor, and a unity gain buffer, the resistor and first capacitor of each bootstrapped filter forming a low-pass filter and the second capacitor is driven to have substantially the same upper and lower alternating current (AC) voltage as when the EEG physiological signal is input into the system, the second capacitor being driven by a common mode signal or a physiological signal potential; and at least one instrumentation amplifier, each instrumentation amplifier comprising at least two amplifiers; wherein the bootstrapped filters are each directly connected to a common node for each of the at least two amplifiers for each of the at least two instrumentation amplifiers, the bootstrapped filters external to each of the instrumentation amplifiers and adapted to remove common mode signal from the physiological signal prior to the signal entering the instrumentation amplifier, and the system is adapted to allow additional channels to be added by adding an additional bootstrapped filter and using an existing channel as a reference and the system is adapted to have a common mode rejection ratio of 95 or greater dB. ### Claim 7 (depends on 6) The system of claim 6, further comprising at least two electrodes and leads for each electrode. ### Claim 8 (depends on 6) The system of claim 6, wherein the leads are shielded from outside electrical interference. ### Claim 9 (depends on 6) The system of claim 6, further comprising a processor wherein EEG signals are transmitted to the processor which is adapted to analyze the EEG signal and to calculate a quantitative EEG (QEEG) index corresponding to a subject's brain or cortical activity level. ### Claim 10 (depends on 9) The system of claim 9, wherein the system further contains software or embedded algorithms that automatically identify artifacts and remove the artifacts from the physiological signal. ### Claim 11 A system for an EEG physiological signal acquisition with analog front-end circuitry comprising: at least two inputs for inputting an EEG physiological signal; at least two bootstrapped filters, each bootstrapped filter comprising a resistor, a first capacitor and a second capacitor, and a unity gain buffer, the resistor and first capacitor forming a low-pass filter and the second capacitor is driven to have substantially the same upper and lower alternating current (AC) voltage as when the EEG physiological signal enters the input, the second capacitor being driven by a common mode signal or a physiological signal potential; and at least one instrumentation amplifier, each instrumentation amplifier comprising at least two amplifiers; wherein each bootstrapped filter is directly connected to a common node of the at least two amplifiers for the instrumentation amplifier, the bootstrap filter being external to the instrumentation amplifier and adapted to remove common mode signal from the physiological signal prior to the signal entering the instrumentation amplifier, and the system has a common mode rejection ratio of 95 or greater dB. ### Claim 12 (depends on 11) The system of claim 11, further comprising at least two electrodes and leads for each electrode. ### Claim 13 (depends on 12) The system of claim 12, wherein the system is adapted to have a common mode rejection ratio of 100 or greater dB. ### Claim 14 (depends on 13) The system of claim 13, wherein the system has a common mode rejection ratio of 105 or greater dB. ### Claim 15 (depends on 13) The system of claim 13, wherein the leads each comprise a shield adapted to shield the leads from outside electrical interference. ### Claim 16 (depends on 13) The system of claim 13, wherein the system further contains software or embedded algorithms that automatically identify artifacts and remove the artifacts from the physiological signal.