# US 11,443,935 B2 · Time-of-flight mass spectrometer > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,443,935 B2 - Document ID: US11443935B2 - Status: Granted - Kind: B2 - Application number: 17/053,397 - Filed: 2018-05-31 - Published: 2021-07-29 - Granted: 2022-09-13 - Earliest claimed: 2018-05-31 - Assignees: Shimadzu Corporation - Applicants: Shimadzu Corporation - Inventors: Shiro Mizutani - Web page: https://patentgrep.com/patent/US11443935B2 ## CPC - H01J 49/403: {characterised by the acceleration optics and/or the extraction fields} - G01N 27/62: by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode - H01J 49/022: {Circuit arrangements, e.g. for generating deviation currents or voltages (regulating electric or magnetic variables in general, e.g. current, magnetic field G05F); Components associated with high voltage supply (high voltage supply per se H02M)} - H01J 49/40: Time-of-flight spectrometers (H01J49/36 takes precedence) - H03K 3/00: Circuits for generating electric pulses; Monostable, bistable or multistable circuits (H03K4/00 takes precedence; for digital function generators in computers G06F1/02) - H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - H03K: PULSE TECHNIQUE (measuring pulse characteristics G01R; modulating sinusoidal oscillations with pulses H03C; transmission of digital information H04L; discriminator circuits detecting phase difference between two signals by counting or integrating cycles of oscillation H03D3/04; automatic control, starting, synchronisation or stabilisation of generators of electronic oscillations or pulses where the type of generator is irrelevant or unspecified H03L; coding, decoding or code conversion, in general H03M) ## Abstract An acceleration voltage generator is configured to cause a power MOSFET to turn on or off to switch a high direct-current voltage, so as to generate a high-voltage pulse for an ejection of ions from an ion ejector. A drive signal is used to cause the power MOSFET to turn on, and further includes a secondary drive signal to recharge a gate capacitance to cause the power MOSFET to stay in an on-state. In a drive signal generator, edge detection circuits generate an edge detection signal based on a start signal; selection circuits generate a primary drive signal by adjusting the edge detection signal in its signal width; and a secondary drive signal generator includes multiple circuit elements such as a semiconductor element, and generates the secondary drive signal. ## Claims ### Claim 1 A time-of-flight mass spectrometer comprising: an ion ejector configured to eject ions to be measured into a flight space by imparting acceleration energy to the ions by an effect of an electric field created by a voltage applied to an electrode; and a high-voltage pulse generator configured to generate a high-voltage pulse for causing an ejection of the ions and apply the high-voltage pulse to the electrode, the high-voltage pulse generator including: a) a direct-current power supply configured to generate a high direct-current voltage; b) a switch circuit including a semiconductor switching element configured to generate the high-voltage pulse by switching the high direct-current voltage; c) a drive signal generator configured to output, as a drive signal, a primary drive signal and a secondary drive signal, each based on a start signal that has a voltage level changed at a timing of the ejection of the ions, the secondary drive signal having a delay from the primary drive signal to cause the semiconductor switching element to stay in an on-state or an off-state, the drive signal generator including a secondary drive signal generator to generate the secondary drive signal, and configured to output, as the drive signal, the primary drive signal that does not pass through the secondary drive signal generator, at least at a timing of causing the semiconductor switching element to turn on in order to cause the ejection of the ions from the ion ejector to start; and d) a switching element drive unit configured to charge or discharge a capacitance of a control terminal of the semiconductor switching element according to the drive signal outputted by the drive signal generator, in order to cause the semiconductor switching element to turn on or stay in the on-state or cause the semiconductor switching element to turn off or stay in the off-state. ### Claim 2 (depends on 1) The time-of-flight mass spectrometer according to claim 1, wherein the drive signal generator further includes an edge detection circuit configured to detect a change in the voltage level of the start signal at the timing of the ejection of the ions, and the primary drive signal is a signal generated based on a signal outputted from the edge detection circuit. ### Claim 3 (depends on 2) The time-of-flight mass spectrometer according to claim 2, wherein the edge detection circuit is a differentiation circuit including a capacitor element and a resistor element. ### Claim 4 (depends on 1) The time-of-flight mass spectrometer according to claim 1, wherein the drive signal generator further includes a drive signal output switching unit configured to switch between a state in which the drive signal is outputted and a state in which outputting of the drive signal is suspended. ### Claim 5 (depends on 1) The time-of-flight mass spectrometer according to claim 1, wherein the secondary drive signal generator includes a positive/negative switching unit configured, based on switching between a positive ionization mode and a negative ionization mode, to invert a polarity of the start signal inputted. ### Claim 6 (depends on 1) The time-of-flight mass spectrometer according to claim 1, wherein the switch circuit includes: a positive-side semiconductor switching element configured, when in an on-state, to output a positive-side voltage from the direct-current power supply to a voltage output terminal; and a negative-side semiconductor switching element configured, when in an on-state, to output a negative-side voltage from the direct-current power supply to the voltage output terminal, the switching element drive unit includes: a first switching element drive unit configured, in response to a first drive signal, to charge the control terminal to a voltage at which the positive-side semiconductor switching element turns on or stays in an on-state; and a second switching element drive unit configured, in response to a second drive signal, to charge the control terminal to a voltage at which the negative-side semiconductor switching element turns on or stays in an on-state, and the secondary drive signal generator further includes a distribution unit configured to distribute a signal based on the start signal inputted to a signal corresponding to the first switching element drive unit and to a signal corresponding to the second switching element drive unit, and based on the signals distributed by the distribution unit, separately generates at a predetermined time interval each of the secondary drive signal to cause the positive-side semiconductor switching element to stay in the on-state or the off-state and the secondary drive signal to cause the negative-side semiconductor switching element to stay in the on-state or the off-state.