Back to results
US 11,442,071 B2Granted
Reusable electrochemical sensors capable of cyclodextrin interactions and methods of use thereof
AssigneeUniversity of New Hampshire
InventorsJeffrey M. Halpern, McKenna Merrill
Life of this patent
Estimating the term…
Abstract
Electrochemical sensor surfaces capable of detecting cortisol at low and high concentrations using cyclodextrin interactions are described. One electrochemical sensor surface uses a cyclodextrin:adamantane complexed surface. Another electrochemical sensor surface uses one or more rotaxanes of surface-bound cyclodextrin.
Claims19
An electrochemical sensor, comprising:
- an electrode comprising a surface modified with a covalently attached monolayer configured to non-covalently attach to cyclodextrin and release cyclodextrin based on contact with a binding analyte.
A method for hydrophobic molecular recognition for electrochemical sensing, comprising:
- contacting a sample with an electrochemical sensor comprising a surface modified with a covalently attached monolayer configured to non-covalently attach to cyclodextrin and release cyclodextrin based on contact with a binding analyte;
- and
- monitoring release of cyclodextrin from the surface.
A method of generating an electrochemical sensor capable of performing a cyclodextrin interaction, comprising:
- modifying a surface of an electrochemical sensor with covalently attached adamantane configured to non-covalently attach to cyclodextrin and release cyclodextrin based on contact with a binding analyte;
- and
- non-covalently attaching cyclodextrin to the adamantane.
Dependencies are inferred from the claim text.