# US 11,442,059 B2 · Method for treating a chronic itch condition by administering small molecule MrgprX4 antagonists

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- Number: US 11,442,059 B2
- Document ID: US11442059B2
- Status: Granted
- Kind: B2
- Application number: 16/623,279
- Filed: 2018-06-15
- Published: 2020-06-04
- Granted: 2022-09-13
- Earliest claimed: 2017-06-16
- Assignees: The Johns Hopkins University
- Applicants: The Johns Hopkins University
- Inventors: Xinzhong Dong; Chirag Vasavda; Solomon H. Snyder; James Meixiong; Yingying Cheng; Nathachit Limjunyawong; Xintong Dong
- Web page: https://patentgrep.com/patent/US11442059B2

## CPC

- G01N 33/5041: {involving analysis of members of signalling pathways}
- C07K 14/705: Receptors; Cell surface antigens; Cell surface determinants {(tumour specific antigens C07K14/4748)}
- C07K 14/723: {G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor}
- C12N 15/63: Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N 15/64: General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
- G01N 33/15: Medicinal preparations {; Physical properties thereof, e.g. dissolubility}
- G01N 33/74: involving hormones {or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors}
- C07K 2319/60: containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
- G01N 2333/726: G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

The present invention relates to cells and methods for detecting compounds that affect G protein coupled receptor mediated conditions. The invention also relates to methods for treating adverse drug reactions, autoimmune disorders, and pruritus.

## Claims

### Claim 1

A method for treating a subject suffering from a chronic itch condition, comprising: administering to the subject a small molecule MrgprX4 antagonist.

### Claim 2 (depends on 1)

The method of claim 1, wherein the chronic itch condition is pruritus.

### Claim 3 (depends on 1)

The method of claim 1, wherein the chronic itch condition is cholestatic pruritus.