Use of leucine-zipper protein for diagnosis or treatment of fatty liver
AssigneeKorea University Research and Business Foundation
InventorsJesang Ko, Min-Soo Kang
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Abstract
The present invention relates to a use of leucine-zipper protein for diagnosis or treatment of fatty liver. According to the present invention, it could be confirmed that a particular fragment present at the leucine-zipper protein, especially, the N-terminal region thereof, plays an important role in the lipid metabolism in liver tissue by regulating transcriptional activity of Apolipoprotein A4, and therefore, the protein of the present invention or a fragment thereof can be utilized as a target for diagnosis, prevention, or treatment of fatty liver.
Claims3
A method for diagnosis of fatty liver, the method comprising a step of measuring the level of a N-terminal fragment of leucine-zipper (LZIP) protein by treating a biological sample obtained from a patient with suspected fatty liver with a probe for measuring the expression or activity of the N-terminal fragment of LZIP protein, wherein the N-terminal fragment of LZIP protein consists of an amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.