# US 11,442,048 B2 · ESI sprayer tube and ESI sprayer > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,442,048 B2 - Document ID: US11442048B2 - Status: Granted - Kind: B2 - Application number: 16/754,154 - Filed: 2017-10-27 - Published: 2021-07-08 - Granted: 2022-09-13 - Earliest claimed: 2017-10-27 - Assignees: Shimadzu Corporation - Applicants: Shimadzu Corporation - Inventors: Wataru Fukui - Web page: https://patentgrep.com/patent/US11442048B2 ## CPC - G01N 30/7266: {by electric field, e.g. electrospray} - G01N 27/623: combined with mass spectrometry - H01J 49/167: {Capillaries and nozzles specially adapted therefor; (electrostatic spraying per se B05B5/00)} - G01N 2030/027: {Liquid chromatography} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H) ## Abstract An ESI sprayer tube 10 includes: a first tube 11 having an inlet end; a second tube 12 having the inner diameter larger than the outer diameter of the first tube 11, the second tube 12 being located outside the first tube 11; and a tube fixation portion 14 formed to fill a space between the first tube 11 and the second tube 12, in a side close to the inlet end. ## Claims ### Claim 1 An ESI sprayer tube which is connected to an outlet tube of a column provided in a liquid chromatograph in use, the ESI sprayer tube comprising: a) a first tube having an inlet end into which a sample liquid enters from the outlet tube; b) a second tube having an inner diameter larger than an outer diameter of the first tube, the second tube being located outside the first tube, where a space is provided between an outer periphery of the first tube and an inner periphery of the second tube; and c) a tube fixation portion configured to fix the first tube and the second tube, the tube fixation portion being formed to fill the space so that the space is completely closed over the outer periphery of the first tube at a side at the inlet end, where an inner diameter of the first tube is smaller than an inner diameter of the outlet tube and such that the tube fixation portion is exposed to the sample liquid from the outlet tube. ### Claim 2 (depends on 1) The ESI sprayer tube according to claim 1, wherein the tube fixation portion is formed by welding. ### Claim 3 (depends on 1) The ESI sprayer tube according to claim 1, wherein the tube fixation portion is formed by soldering. ### Claim 4 (depends on 1) The ESI sprayer tube according to claim 1, wherein the second tube is shorter than the first tube. ### Claim 5 (depends on 1) The ESI sprayer tube according to claim 1 having an end opposite to the inlet end, wherein at least a portion of the first tube and a portion of the second tube at the end are configured to create a tapered outer shape. ### Claim 6 (depends on 1) The ESI sprayer tube according to claim 1, wherein the first tube is made of a conductive material. ### Claim 7 (depends on 1) The ESI sprayer tube according to claim 1, wherein the first tube and the second tube are both made of a conductive material. ### Claim 8 (depends on 1) The ESI sprayer tube according to claim 1, wherein the first tube and the second tube are made of a same material. ### Claim 9 (depends on 1) An ESI sprayer comprising: the ESI sprayer tube according to claim 1; and a voltage application section configured to apply voltage to the first tube. ### Claim 10 (depends on 9) The ESI sprayer according to claim 9, wherein the voltage application section is configured to apply voltage to the first tube via the second tube. ### Claim 11 (depends on 1) The ESI sprayer tube according to claim 1, wherein the inner diameter of the second tube is larger than the outer diameter of the first tube over the entire length of the second tube in an axial direction. ### Claim 12 (depends on 1) The ESI sprayer tube according to claim 1, further comprising a third tube, the third tube having an inner diameter larger than an outer diameter of the second tube. ### Claim 13 (depends on 1) The ESI sprayer tube according to claim 1, wherein an end of the first and an end of the second tube are positioned at the same position, in an axial direction, at the inlet end. ### Claim 14 (depends on 1) The ESI sprayer tube according to claim 1, wherein the tube fixation portion is further configured to fill a space between the first tube and the second tube at an end opposite to the inlet end. ### Claim 15 (depends on 12) The ESI sprayer tube according to claim 12, wherein the tube fixation portion is further configured to fix the second tube and the third tube, the tube fixation portion being further formed to fill a space between the second tube and the third tube at the inlet end. ### Claim 16 (depends on 9) The ESI sprayer according to claim 9, wherein the second tube has an inner diameter larger than an outer diameter of the first tube over an entire length of the second tube in an axial direction.