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US 11,441,147 B2Granted
RNAi for the control of phytopathogenic fungi and oomycetes by inhibiting the expression of CYP51 genes
AssigneeBASF SE
InventorKarl-Heinz Kogel
Life of this patent
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Abstract
The present invention relates to dsRNA molecules for inhibiting the expression of CYP51 gene(s) from a fungal or oomycete phytopathogen and the use of such inhibitory dsRNA molecules for controlling phytopathogenic fungi and/or oomycetes. The present invention further relates to DNA sequences providing a transcriptional template for inhibitory dsRNA molecules or antisense RNA; and phytopathogen-tolerant transgenic plants with such DNA sequences.
Claims24
A dsRNA molecule for inhibiting the expression of the CYP51A gene, the CYP51B gene and the CYP51C gene from Fusarium graminearum, the dsRNA comprising:
- i. a sense sequence being at least 90% identical to at least 50 contiguous nucleotides and having 100% sequence identity to at least 20 contiguous nucleotides of the coding sequence of the CYP51A gene set forth in SEQ ID NO:
- 1;
- ii. a sense sequence being at least 90% identical to at least 50 contiguous nucleotides and having 100% sequence identity to at least 20 contiguous nucleotides of the coding sequence of the CYP51B gene set forth in SEQ ID NO:
- 2;
- iii. a sense sequence being at least 90% identical to at least 50 contiguous nucleotides and having 100% sequence identity to at least 20 contiguous nucleotides of the coding sequence of the CYP51C gene set forth in SEQ ID NO:
- 3;
- and
- iv. antisense sequences being complementary to each of the sense sequences (i), (ii), and (iii);
- wherein the arrangement of the sequences within the dsRNA molecule allows hybridization of each sense sequence with its complementary antisense sequence.
6 more elements
Dependencies are inferred from the claim text.