# US 11,441,112 B2 · Incubation device and system comprising incubation device and rocking platform

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- Number: US 11,441,112 B2
- Document ID: US11441112B2
- Status: Granted
- Kind: B2
- Application number: 16/429,143
- Filed: 2019-06-03
- Published: 2019-09-19
- Granted: 2022-09-13
- Earliest claimed: 2017-09-22
- Assignees: EUROIMMUN Medizinische Labordiagnostika AG
- Applicants: EUROIMMUN Medizinische Labordiagnostika AG
- Inventors: Christian Kaffka; Martin Rateike; Winfried Stöcker
- Web page: https://patentgrep.com/patent/US11441112B2

## CPC

- C12M 27/16: {Vibrating; Shaking; Tilting}
- B01F 31/23: by pivoting the containers about an axis
- B01L 9/52: {Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips}
- C12M 41/14: {Incubators; Climatic chambers (per se B01L1/00)}
- G01N 1/312: {for samples mounted on planar substrates}
- B01F 2101/44: Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
- B01L 1/00: Enclosures; Chambers (provided with manipulation devices or glove boxes B25J21/00)
- B01L 3/50855: {using modular assemblies of strips or of individual wells}
- B01L 7/04: Heat insulating devices, e.g. jackets for flasks
- B01L 2300/0822: Slides
- B01L 2300/0877: Flow chambers
- B01L 2400/0433: vibrational forces
- B01L 2400/0475: specific mechanical means and fluid pressure
- B01L 2400/049: vacuum
- C12M: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; {APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS}
- B01F: MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING (mixing paints B44D3/06)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

An incubation device has multiple rocking platforms with each platform pivotally mounted about a respective axis. Each rocking platform has a respective receiving device for mechanically reversibly receiving a respective incubation channel. The device also has a common drive unit for common respective rocking movements of each platform from a zero position through with a specific angle range as a result of movement of the drive unit. Each rocking platform is coupled to the drive unit via a respective coupling mechanism, and each coupling mechanism elastically and resiliently couples the respective rocking platform to the drive unit, such that when the rocking platform is restrained, despite continuation of the drive movement, the rocking platform remains motionless in a fixed position. After release of the restraint on the rocking platform, the rocking platform resumes the rocking movement with the specific angle range.

## Claims

### Claim 1

An incubation device, comprising:
a multiplicity of rocking platforms, which are respectively mounted tiltably about a respective axis, the respective rocking platform comprising a respective reception device for mechanically reversible reception of a respective incubation tray,
a common drive unit for common generation of respective rocking movements of the respective rocking platforms through a particular angle range on the basis of a drive movement of the drive unit,
wherein each of the respective rocking platforms is coupled to the common drive unit by a respective coupling mechanism, and
wherein each of the respective coupling mechanisms elastically resiliently couples the respective rocking platform to the common drive unit in such a way that, when the rocking platform is restrained, the rocking platform remains in a fixed position despite continuation of the drive movement, but furthermore, after the restraint of the rocking platform is ended, the rocking platform again carries out the rocking movement through the particular angle range because of the drive movement,
wherein the coupling mechanism comprises at least one elastic spring element, which is configured in such a way that the at least one elastic spring element is elastically deformed in the event of application of a holding force to restrain the rocking platform and simultaneous continuation of the drive movement.

### Claim 2 (depends on 1)

The incubation device as claimed in claim 1,
wherein the rocking platform comprises a force reception element arranged eccentrically with respect to the axis of the rocking platform, the deflection of which about an axis midpoint causes tilting of the rocking platform,
wherein the coupling mechanism further comprises at least one pusher element which, because of the drive movement of the common drive unit, generates a force on the force reception element to deflect the force reception element,
and wherein a force transmission from the pusher element to the force reception element is coupled to the at least one elastic spring element.

### Claim 3 (depends on 1)

The incubation device as claimed in claim 1, further comprising a holding device for restraining at least one of the rocking platforms in the fixed position.

### Claim 4 (depends on 3)

The incubation device as claimed in claim 3,
wherein the common drive unit is arranged below the rocking platform,
wherein the holding device comprises on its lower side an engagement element having an essentially convex geometrical shape,
wherein the rocking platform further comprises on its upper side an engagement recess having an essentially concave geometrical shape, which corresponds with the convex geometrical shape of the engagement element, and
wherein movement of the holding device from above in a direction of the upper side of the rocking platform causes engagement of the engagement element in the engagement recess in order to prevent the rocking movement of the rocking platform in the fixed position.

### Claim 5 (depends on 1)

The incubation device as claimed in claim 1,
wherein the rocking platform further comprises a metal element, which is firmly mechanically coupled to the rocking platform and carries out the rocking movement together with the rocking platform,
wherein the incubation device further comprises an electromagnet and a control unit,
wherein the control unit is configured to drive the holding device in such a way that the holding device restrains the rocking platform in the fixed position, and furthermore subsequently to activate the electromagnet so that a magnetic force between the electromagnet and the metal element also restrains the rocking platform in the fixed position when the holding device no longer restrains the rocking platform.

### Claim 6 (depends on 5)

The incubation device as claimed in claim 5, wherein the holding device restrains the rocking platform in the fixed position by engaging the engagement element in the engagement recess.

### Claim 7 (depends on 1)

The incubation device as claimed in claim 1, wherein the reception device is configured with an upwardly open opening on an upper side of the rocking platform, into which the incubation tray can be inserted.

### Claim 8 (depends on 7)

The incubation device as claimed in claim 7,
wherein the reception device comprises a bottom on which a lower side of the incubation tray bears in an inserted state, and
wherein the reception device further comprises a clamping mechanism in order to hold the lower side of the incubation tray on the bottom.

### Claim 9 (depends on 8)

The incubation device as claimed in claim 8,
wherein the rocking platform further comprises a heating device for heating the bottom.

### Claim 10 (depends on 1)

A system, comprising:
the incubation device as claimed in claim 1 and at least one of the incubation tray which can be placed in the rocking platform.

### Claim 11 (depends on 10)

The system as claimed in claim 10,
wherein the incubation tray comprises an indentation, formed by walls of the incubation tray, having an indentation bottom,
wherein the incubation tray comprises at least one opening which opens into a channel at a longitudinal end of the indentation, so that liquid can be introduced into the indentation, or aspirated, through the channel,
wherein a carrier may be placed in the incubation tray, which carrier comprises a sample on its lower side, which faces toward the indentation bottom, when it is placed in the incubation tray, so that the lower side of the carrier, the indentation bottom and the walls form a compartment for the liquid.

### Claim 12 (depends on 11)

The system as claimed in claim 11,
wherein the incubation tray comprises means for fixing a distance between the lower side of the carrier and the indentation bottom such that the lower side of the carrier, the indentation bottom and the walls form the compartment for the liquid.

### Claim 13 (depends on 12)

The system as claimed in claim 12, wherein the means for fixing a distance between the lower side of the carrier and the indentation bottom comprise a bearing chamfer.

### Claim 14 (depends on 11)

The system as claimed in claim 11, wherein the at least one opening is placed in the walls of the incubation tray.