Method for preparing cangrelor tetrasodium salt
AssigneeYabao Pharmaceutical Group Co., Ltd.
InventorsFanghui Tang, Jiyu Bao, Junfeng Gao, Zhouhong Tan
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Abstract
The present application relates to a method for prepare a Cangrelor tetrasodium salt, comprising: using N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)sulfonyl]adenosine as a raw material to undergo two steps of reaction to obtain a reaction solution containing the Cangrelor tetrasodium salt; separating and purifying once by C18 silica gel column chromatography so as to obtain a Cangrelor tetrasodium salt pure product. The present application has the advantages of short synthesis route, mild reaction conditions, sufficient reaction, simple operation, high product yield, high purity, and environmental friendliness, and is suitable for large-scale preparation.
Claims18
A method for preparing Cangrelor tetrasodium salt, comprising the following steps:
- step (1), reacting a compound C with phosphorus oxychloride in an organic solvent to obtain a reaction solution containing a compound B;
- step (2), reacting the reaction solution containing the compound B obtained in step (1) with clodronic acid or a monosalt thereof in the presence of an acid-binding agent, and then with sodium bicarbonate to obtain a reaction solution containing Cangrelor tetrasodium salt;
- and
- step (3), obtaining Cangrelor tetrasodium salt from the reaction solution containing Cangrelor tetrasodium salt obtained in step (2);
- wherein the step (3) is a step of separating and purifying the reaction solution containing Cangrelor tetrasodium salt obtained in step (2) by C18 silica gel column chromatography, eluting with an eluent, collecting the eluate of Cangrelor tetrasodium salt with a HPLC purity≥99.5% and lyophilizing to obtain Cangrelor tetrasodium salt.
Dependencies are inferred from the claim text.