# US 11,440,931 B2 · Crocins compounds and uses thereof

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- Number: US 11,440,931 B2
- Document ID: US11440931B2
- Status: Granted
- Kind: B2
- Application number: 16/097,166
- Filed: 2017-03-16
- Published: 2019-06-13
- Granted: 2022-09-13
- Earliest claimed: 2016-04-29
- Assignees: Jinan University
- Applicants: Jinan University
- Inventors: Xinsheng Yao; Yang Yu; Dan Zhang; Yang Ni; Xiuqi Bao; Lin Li; Caixía Zang; Hao Gao; Yuanpeng Zheng
- Web page: https://patentgrep.com/patent/US11440931B2

## CPC

- C07H 13/06: Fatty acids
- A61K 31/7024: Esters of saccharides
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C07H 1/08: from natural products
- C07H 13/04: having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

## Claims

### Claim 1

A method for inhibiting or treating Alzheimer's disease in a subject, which comprises administering an effective amount of a crocin-like compound or a pharmaceutically acceptable salt thereof to the subject, wherein the crocin-like compound is selected from
and pharmaceutically acceptable salts thereof.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the compound is

### Claim 3 (depends on 1)

The method according to claim 1, wherein the compound is